Jody Baron
Our experiments seek to use and extend our transgenic model of primay HBV infection to identify the mechanisms involved acute and chronic hepatitis. Our long term goal is to develop a more comprehensive understanding of the role of both innate and adaptive immunity in HBV clearance and virus-induced liver damage.

Other Research in Dr. Baron's Lab
Inflammation • Immune Receptors and Signaling

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Warner Greene
My laboratory investigates how powerful intrinsic antiviral factors, the APOBEC3's, achieve their effects, how viruses mount counterstrikes against the APOBEC3's, and the potential role of the APOBEC3G as a regulator of endogenous retroelement retrotransposition. A second line of study seeks to define the molecular basis for HIV latency and to derive new approaches for purging HIV from the latent reservoir, a requirement if a "cure" for HIV infected patients is ever to be realized. A third area of study explores the biology of HIV in dendritic cells to understand the molecular underpinnings of HIV transmission.

Other Research in Dr. Greene's Lab
Inflammation

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Nigel Killeen
We are using viral systems to determine how the involvement of OX40 costimulation improves the outcome of immune responses in terms of the formation of more effective memory T cells. Genetic lineage marking strategies offer the opportunity to gain unique insight into the basis of memory cell formation and the most effective way to develop vaccines that confer long-lived protection.

Other Research in Dr. Killeen's lab:
Allergy and Asthma, Diabetes and Autoimmunity, Development and Differentiation, Immune Regulation, Immune Receptors and Signaling, Immune Response to Microbial Pathogens

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Lewis Lanier
NK cells mediate innate immunity against virus-infected cells. They are particularly important in immunity against cytomegalovirus (CMV) and other double-stranded DNA viruses. In mice, members of the Ly49 family of NK receptors recognize cytomegalovirus and cause the activation of NK cells, resulting in the secretion of cytokine and the killing of CMV-infected cells. We have shown that the Ly49H receptor directly recognizes a glycoprotein, m157, encoded by mouse cytomegalovirus (Arase et al., Science. 2002 May 17;296(5571):1323-6). In response to selective pressure imposed by NK cells, CMV has evolved genes encoding viral protein that evade NK cell recognition. For example, we have identified two mouse CMV genes, m152 and m155, that prevent NK cell recognition of CMV-infected cells Lodoen et al., J Exp Med. 2003 May 19;197(10):1245-53 and Lodoen, et al. J Exp Med. 2004 Oct 18;200(8):1075-81.). Our lab focuses on the role of NK cells in immune responses to CMV and other viruses.

Featured Articles:
Arase et al., Science 2002.
Lodoen et al., J Exp Med. 2003
Lodoen et al., J Exp Med. 2004

Other Research in Dr. Lanier's Lab
Diabetes and Autoimmunity • Immune Receptors and Signaling • Tumor Immunology

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Mike McCune
Research in the McCune lab focuses on the definition of pathogenic mechanisms of viral diseases, particularly HIV-1 disease. This focus has spanned a range of fields, from understanding critical structural determinants of infectivity, to devising a small animal model (the SCID-hu Thy/Liv mouse) to study HIV pathogenesis and to prioritize antiretroviral compounds against HIV, to studying mechanisms of T cell depletion and repletion in vivo. This body of work has engaged in hypothesis-driven, patient-oriented research that has involved collaborative teams of basic scientists, translational researchers, and clinicians. Most recently, ever more attention is being devoted to understanding the correlates of protective immunity against HIV, with the specific intent to work with others to develop an effective vaccine. This change of focus has now been materialized at UCSF by the creation of the Division of Experimental Medicine, of which Dr. McCune is the Chief.

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Marion Peters
Host-viral interactions in Hepatitis C B infection. This project evaluates the role of inflammatory cytokines and their receptors using DNA polymorphism analysis and mRNA gene profiling. We assess the effect of the host response on severity of disease and response to therapy including the effects of alcohol, obesity and HIV co-infection.

Other Research in Dr. Peters' Lab
Diabetes and Autoimmunity • Inflammation

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