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Immunology Program Faculty

Zena Werb, PhD

Functional Genomics of Extracellular Proteolysis in Development and Cancer

Professor and Vice-Chair, Department of Anatomy
513 Parnassus Avenue, Rm. 1321
San Francisco, CA 94143-0452

(415) 476-4622 tel
zena.werb@ucsf.edu

Lab website


Description of Research
The Werb lab is interested in the recruitment and function of the innate and acquired immune system in development and disease. In particular we study the role of inflammatory cells in mammary gland development and progression of neoplasia using specific gene ablations and invivo imaging methods to analyze cell behavior.

Selected Publications

Coussens, L.M. & Z. Werb (2002). Inflammation and cancer. Nature 420:860-867.

Egeblad, M. & Z. Werb (2002). New roles for the matrix metalloproteinases in the progression of cancer. Nature Rev. Cancer. 2: 163-176.

Affolter, M., S. Bellusci, N. Itoh, B. Shilo, J.-P. Thiery & Z. Werb (2003). Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev. Cell.4: 11-18.

Li, Y., B. Welm, K. P., S. Huang, M. Chamorro, T. Rowlands, P. Cowin, M. Egeblad, Z. Werb, L. K. Tan, J. Rosen & H. E. Varmus (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA. 100: 15853-1585.

Wiseman, B.S., M. D. Sternlicht, L. R. Lund, C. M. Alexander, J. Mott, M. J. Bissell, P. Soloway, S. Itohara & Z. Werb (2003). Site-specific positive and negative activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J. Cell Biol. 162: 1123-1133.

Stickens, D., D. J. Behonick, N. Ortega, B. Heyer, B. Hartenstein, Y. Yu, M. Schorpp-Kistner, A. Fosang, P. Angel & Z. Werb (2004). Altered endochondral bone formation in matrix metalloproteinase-13 deficient mice. Development. 131: 5883-5895.

Littlepage, L.E., M. Egeblad & Z. Werb (2005). Coevolution of cancer and stromal cellular responses. Cancer Cell. 7:499-500.

Ortega, N., D. J. Behonick, C. Colnot, D. H. Cooper & Z. Werb (2005). Galectin-3 is a downstream regulator of MMP-9 function during endochondral bone formation. Mol. Biol. Cell. 16: 3028-3039.

Radisky, D. C., D. D. Levy, L. E. Littlepage, H. Liu, C. M. Nelson, J. E. Fata, D. Leake, E. L. Godden, D. G. Albertson, M.A. Nieto, Z. Werb & M. J. Bissell. (2005). Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123-127.

Sternlicht, M.D., S.W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee & Z. Werb (2005). Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 132:3923-3933.

Stickens, D., B. M. Zak, N. Rougier, J. D. Esko & Z. Werb (2005). Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 132:5055-5068.

Kouros-Mehr, H. & Z. Werb (2006). Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev. Dyn. 235:3404-3412.

Kouros-Mehr, H., E. M. Slorach, M. D. Sternlicht & Z. Werb (2006). GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 127:1041-1055

Liu, Z., X. Zhou, L. A. Diaz, R. M. Senior & Z. Werb (2005). Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J. Clin. Invest. 115: 879-887.

Sternlicht, M. D., A. M. Dunning, D. H. Moore, P. D. P. Pharoah, D. G. Ginzinger, K. Chin, J. W. Gray, F. M. Waldman, B. A. J. Ponder & Z. Werb (2006). Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Canc. Epidemiol. Biomarkers. Prev. 15: 2107-2114.

Fata, J.E., H. Mori, A. J. Ewald, H. Zhang, E. Yao, Z. Werb & M. J. Bissell (2007). The MAPK ERK-1,2 pathway integrates distinct and antagonistic signals from TGF a and FGF7 in morphogenesis of mouse mammary epithelium. Dev. Biol. [ Epub 16 March 2007 ].

Lum, D.H., J. Tan, S. D. Rosen & Z. Werb (2007). Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase, Sulf2. Mol. Cell. Biol. 27:678-688.

Page-McCaw, A., A. J. Ewald & Z. Werb (2007). Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. Nat. Rev. Mol. Cell Biol. 8: 221-233.


Lab Members
Not available.

Last Updated October 8, 2007

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