i m m u n o l o g y   g r a d u a t e   p r o g r a m

Looking toward the Pacific Ocean from UCSF's Parnassus campus.
(Courtesy of Art Weiss, MD, PhD)

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Immunology Program Faculty

Arthur Weiss, MD, PhD

Signal Transduction Events in T Lymphocytes

Investigator, Howard Hughes Medical Institute
Ephraim P. Engleman Distinguished Professor
Department of Medicine, Division of Rheumatology
Department of Microbiology and Immunology
513 Parnassus, Room S-1032C, Box 0795
San Francisco, CA 94143-0795

(415) 476-8983 tel
(415) 502-5081 fax
aweiss@medicine.ucsf.edu

AA: Mary Anne Ford
415-476-1291 tel


Description of Research
The response of lymphocytes to antigen presents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate gene expression. We would like to understand how the molecules in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

Selected Publications


Deindl, S., Kadlecek, T.A., Brdicka, T., Cao, X., Weiss, A., and Kuriyan. Structural basis for the inhibition of the tyrosine kinase activity of ZAP-70. Cell, 129:735-746, 2007.

Zhu, J.W., Brdicka, T., Katsumoto, T.R., Lin, J., and Weiss, A. Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 28:183-196. 2008.

Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A.K., and Roose, J.P. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell, 136:337-351. 2009.

Phee, H., Dzhagalov, I., Mollenauer, M., Wang, Y., Irvine, D.J., Robey, E., and Weiss, A. Regulation of thymocyte positive selection and motility by GIT2. Nat. Immunol., 11:503-511. 2010.

Zikherman, J., Jenne, C., Watson, S., Doan, K., Raschke, W., Goodnow, C.C., and Weiss, A. The balance between positive and negative regulatory roles of CD45 during T CR signaling varies throughout T cell development. Immunity, 32:342-354. 2010.

Au-Yeung, B.B., Levin, S.E., Zhang, C., Hsu, L.-Y., Cheng, D.A., Killeen, N., Shokat, K and Weiss, A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol., 11:1085-1093. 2010.

Limnander, A., Depeille, P., Freedman, T.S., Liou, J., Leitges, M., Kurosaki, T., Roose, J.P., and Weiss, A. Stim1, PKCd, and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development. Nat. Immunol., 12:425-433. 2011.

Schoenborn, J.R, Tan, X.T., Zhang, C., Shokat, K., and Weiss, A. Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling. Science Signaling. Sep 13;4(190):ra59 2011.

Zhu, J.W., Doan, K., Park, J., Chau, A.H., Zhang, H., Lowell, C.A., and Weiss, A. Distinct functions of receptor-like tyrosine phosphatases CD45 and CD148 in chemoattractant-mediated neutrophil migration and response to S. aureus infection. Immunity. In press. 2011.


Lab Members

Postdoctoral Fellows
Byron Au-Yeung, PhD Henrik Flach, PhD
Tanya Freedman, PhD
Lyn Hsu, PhD
Tamiko Katsumoto, MD Boryana Manz, PhD Hyewon Phee, PhD
Hanna Sjolin-Goodfellow Haopeng Wang, PhD
Jing Zhu, PhD
Julie Zikherman, PhD

Graduate Students
Kasia Skrzypczynska
Ying Xim Tan

Research Technicians
Debra Cheng
Terri Kadlecek
Marianne Mollenauer (Lab Manager)
Ramya Parameswaran

Al Roque
Kerri Tam


Administrative Assistant

Mary Anne Ford
Phone: 415-476-1291


Last Updated October 11, 2011

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