Our laboratory is primarily interested in immune receptors and the signaling mechanisms by which they alter cell function. The laboratory has recently identified TIM-2 on B cell, particularly germinal center B cells, and has shown that it is an endocytosing receptor for H-ferritin. We have shown that another receptor, TREM-2, which is expressed on immature dendritic cells, binds broadly to bacteria. TREM-2 activates Syk tyrosine kinase through an adapter protein, DAP12. The laboratory is currently studying the mechanisms by which TREM-2 subsequently alters cell function. |
Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE , Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3;202(7):955-65.
Chen TT, Brown EJ, Huang EJ, Seaman WE . Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 1;64(1):117-27.
Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE , Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15;171(12):6541-8.
Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE . Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15;171(2):594-9.
Gilman AG, Simon MI, Bourne HR, et al. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12;420(6916):703-6.
Chung DH, Seaman WE , Daws MR. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 Jan;32(1):59-66.
Nakamura MC, Seaman WE . Ligand interactions by activating and inhibitory Ly-49 receptors. Immunol Rev. 2001 Jun;181:138-48.
Daws MR, Lanier LL, Seaman WE , Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar;31(3):783-91.
Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE . Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). J Exp Med. 2000 Aug 7;192(3):447-54.
Seaman WE . Natural killer cells and natural killer T cells. Arthritis Rheum. 2000 Jun;43(6):1204-17. |
