Immunology Graduate Program | University of California, San Francisco

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Immunology Program Faculty

Edward Goetzl, MD Immune Effector Mechanism in Allergy and Inflammation Robert L. Kroc Professor, Department of Medicine Professor, Department of Microbiology and Immunology 533 Parnassus Avenue, Rm UB8B, Box 0711 San Francisco , CA 94112-2203 (415) 476-5339 Email Lab website AA: Robert Chan, (415) 476-9892

Description of Research
Dr. Goetzl's laboratory is investigating non-migration effects of the lipid mediator sphingosine 1-phosphate (S1P) on T cell cytokine generation, that are transduced by T cell type 1 S1P G protein-coupled receptors (S1P1 Rs). In a TGFb and IL-6 environment, the S1P-S1P1 R axis evokes differentiation of Th17 effector cells from naïve CD4 T cells. In contrast, the S1P-S1P1 R system promotes conversion of naïve CD4 T cells to adaptive T reg cells in the presence of IL-4 without TGFb or IL-6. The T cell signaling pathways involved and the consequences for immunity and autoimmune disease potential are being studied in S1P1 R transgenic and knock-out mice with a range of selective pharmacological tools.

Selected Publications
Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol. 2005 Jul;5(7):560-70. Liao JJ, Huang MC, Graler M, Huang Y, Qiu H, Goetzl EJ. Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. J Biol Chem. 2007 Jan 19;282(3):1964-72. Epub 2006 Nov 22. Wang W, Huang MC, Goetzl EJ. Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice. J Immunol. 2007 Apr 15;178(8):4885-90. Liao JJ, Huang MC, Goetzl EJ. Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. J Immunol. 2007 May 1;178(9):5425-8. Huang MC, Watson SR, Liao JJ, Goetzl EJ. Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. J Immunol. 2007 Jun 1;178(11):6806-13.

Lab Members
Asst Research Immunologist Mei-Chuan Huang Postdoctoral Scholars Mahesh Yadav Qun Dai Junior Specialists Jia-Jun Liao Jennifer Rosenbaum Research Services Associates Yvonne Kong Mercedes Joaquin	Administrative Assistant Robert Chan (415) 476-9892 Research Analyst Chude Allen (415) 476-5025

Last Updated October 8, 2007