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| Immunology Program Faculty |
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Jeff Cox, PhD
Host-Pathogen Interactions Responsible for M. tuberculosis Virulence
Associate Professor, Dept. of Microbiology and Immunology
UCSF Mission Bay Campus, Genentech Hall N376
600 16th Street, Box 2200
San Francisco CA 94143-2200
(415) 502-4240 tel
jeffery.cox@ucsf.edu |
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Our interests lie at the interface of prokaryotic and eukaryotic biology during bacterial infections. In particular, we study the notorious human pathogen Mycobacterium tuberculosis, which is remarkably adept at subverting host immune cell function. We use genetics as a primary tool to identify bacterial genes required for pathogenesis, as well as employ a wide variety of complementary approaches to understand how the bacterium interacts with and alters its immune-cell niche, the macrophage. |
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| Selected Publications |
Cox JS, Chen B, McNeil M, and Jacobs WR. (1999) Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 402: 79-83.
Glickman MS, Cox JS, and Jacobs WR. (2000) A novel mycolic acid cyclopropane synthetase is required for coding, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5: 717-27.
Zimhony O, Cox JS, Welch JT, Vilcheze C, and Jacobs WR. (2000) Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med 6: 1043-7. |
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| Lab Members |
Postdocs
Elizabeth Mathew
Michael Shiloh
Patty Champion |
Graduate Students
Madhulika Jain
Jason MacGurn
Scott Converse
Sridharan Raghavan
Yamini Ohol
Holly Ramage |
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Last Updated
September 17, 2009
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