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Micro 209. The science of immunological diseases: translating basic research to the clinic.
Course Directors: Abul Abbas, MD; Averil Ma , MD; Mark Anderson, MD, PhD.
This course is scheduled for
Fall 2008.
Course description:
This course will discuss the pathogenesis of selected immune-mediated inflammatory diseases, and the clinical features and therapeutic approaches for these diseases. Sessions will consist of lectures, discussion of seminal papers (in the format of student-run journal clubs), and interviews with patients. At the end of the course, students are expected to have a better appreciation of: the links between basic immunology and the development of immunological diseases; the application of animal models to understanding disease pathogenesis; modern technologies for studying patients; and the principles underlying rational drug design and development for inflammatory diseases.
The course is open to graduate, medical and MSTP students. A basic Immunology course is a pre-requisite for registering for this course. The basic course may be Micro 204 for graduate students or the Immunology component of I-3 for medical students. Evaluations will be based on participation in journal clubs and class discussions and a take-home exam with essay questions at the end of the course.
Tentative course schedule:
The course will be held on Mondays from 1:30 to 3:30 pm in the fall of 2008. The planned agenda is as follows:
| September 22 |
Introduction: Self-tolerance, autoimmunity and immune-mediated inflammatory diseases. |
Abul Abbas |
| September 29 |
Rheumatoid arthritis I. Basic science: Pathogenesis; discussion of two selected papers. |
John Imboden |
| October 6 |
Rheumatoid arthritis II. Clinical aspects: clinical features, therapies, patient interview. |
John Imboden |
| October 20 |
Inflammatory bowel disease I. Basic science: Pathogenesis; discussion of two selected papers. |
Averil Ma |
| October 27 |
Inflammatory bowel disease II. Clinical aspects: clinical features, therapies, patient interview. |
Averil Ma |
| November 3 |
Type 1 diabetes I. Basic science: Pathogenesis; discussion of two selected papers. |
Mark Anderson |
| November 10 |
Type 1 diabetes II. Clinical aspects: clinical features, therapies, patient interview. |
Mark Anderson |
| November 17 |
Multiple sclerosis I. Basic science: Pathogenesis; discussion of two selected papers. |
Steve Hauser |
| November 24 |
Multiple sclerosis II. Clinical aspects: clinical features, therapies, patient interview. |
Steve Hauser |
| December 1 |
Novel immune therapies: rational drug design based on scientific principles. |
Andrew Chan, Genentech. |
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