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Microbiology 204 Molecular and Cellular Immunology
This is an introductory graduate level course open to students from BMS, PIBS, Pharmaceutical Chemistry and other UCSF graduate programs.
Course Director
Anthony DeFranco
email: anthony.defranco@ucsf.edu
phone:(415) 476-5488
Topics
Mechanisms of immunoglobulin gene rearrangements, cell biology of antigen presentation to T-cells and of lymphocyte trafficking, antigen and cytokine receptor structure and signal transduction mechanisms, regulation of lymphocyte development and lymphocyte activation, mechanisms of cell-mediated killing of infected and neoplastic cells, whole organism immune response to infection, and diseases of the immune system, including allergy, autoimmunity, and AIDS.
Course Details
Course meets three times per week, Monday, Wednesday,
and Friday from 1-2:30pm . The class will be broadcast
to Mission Bay (room Gen. S-202). About 3/4 of the course
will be lectures; the other 1/4 will be discussion sections.
Please see the calendar below for locations.
Grades will be based on participation in discussion sections and performance on take-home final exam.
Note: Lecture portion of the course is open to auditors. Auditors wishing to take part in the discussion sections must have prior consent of the instructor.
Prerequisites
None, but some background in molecular biology and cell biology would be useful.
Teaching Assistants
Megan McSweeney (megan.mcsweeney@ucsf.edu)
2009 Schedule
DAY |
DATE |
ROOM |
LECTURE |
LECTURER |
DOWNLOADS |
| Friday |
9/25 |
N-217/
GEN-S271 |
Overview of the Immune System |
DeFranco |
Download PPT |
| Monday |
9/28 |
N-225/
GEN-S202 |
Innate Immunity
|
DeFranco |
Download PPT
Download Read List
|
| Wednesday |
9/30 |
N-217/
GEN-S202 |
Homing/Inflammation |
Cyster |
Download PPT
|
| Friday |
10/2 |
N-217/
GEN-S202 |
MHC/Antigen Presentation |
Weiss |
Download PPT
Download Read List |
| Monday |
10/5 |
S-163 |
Discussion |
Hermiston |
Instructions
Download Document
Online Journal |
| Wednesday |
10/7 |
N-217/
(Mission Bay Viewing Cancelled
GEN-S271) |
T Cell Antigen Receptors |
Weiss |
Download PPT
Download Read List |
| Friday |
10/9 |
N-217/
GEN-S271 |
TCR Signaling |
Weiss |
Download PPT
Download Read List |
| Monday |
10/12 |
|
No Session
(BMS Retreat) |
|
|
| Wednesday |
10/14 |
N-217/
GEN-S202 |
T Cell Development |
Weiss |
Download PPT
Download Read List |
| Friday |
10/16 |
S-168 |
Discussion |
Matloubian |
|
| Monday |
10/19 |
HSW-300/
GEN-S202 |
Antibodies/Ig Genes |
DeFranco |
Download PPT
Download Read List |
| Wednesday |
10/21 |
N-217/
GEN-S271 |
B Cell Development & Tolerance |
DeFranco |
Download PPT
Download Read List |
| Friday |
10/23 |
|
No Session
(Immuno Retreat) |
|
|
| Monday |
10/26 |
S-163 |
Discussion |
Matloubian |
|
| Wednesday |
10/28 |
N-217/
GEN-S202 |
Anatomy of Immune Responses |
Cyster |
Download PPT |
| Friday |
10/30 |
N-217/
GEN-S271 |
B Cell Activation |
Cyster |
Download PPT |
| Monday |
11/2 |
N-225/
GEN-S202 |
T Cell Activation |
Anderson |
|
| Wednesday |
11/4 |
N-217/
GEN-S202 |
Cytokines/Th1/Th2
|
Locksley |
Download PPT |
| Friday |
11/6 |
S-180 |
Discussion |
Hermiston |
|
| Monday |
11/9 |
N-217/
GEN-S202 |
Effector T cell Functions |
Lanier |
Download PPT
Download Read List
|
| Wednesday |
11/11 |
|
No Session
(Veteran's Day)
|
|
|
| Friday |
11/13 |
N-217/
GEN-S202 |
T Cell Tolerance |
Anderson |
|
| Monday |
11/16 |
N-217/
GEN-S202 |
Autoimmunity |
Anderson |
|
| Wednesday |
11/18 |
N-217/
GEN-S202 |
NK Cell Recognition
|
Lanier |
Download PPT
Download Read List |
| Friday |
11/20 |
N-217/
GEN-S202 |
Defense against Bacteria/Parasites |
Locksley |
Download PPT |
| Monday |
11/23 |
N-217/
GEN-S202 |
Defense against Viruses/Aids |
Locksley |
|
| Wednesday |
11/25 |
S-157 |
Discussion
|
Lowell |
|
| Friday |
11/27 |
|
(THANKSGIVING HOLIDAY) |
|
|
| Monday |
11/30 |
N-217/
GEN-S202 |
Allergy
and Asthma |
Locksley |
|
| Wednesday |
12/2 |
S-168 |
Discussion |
Lowell
|
|
| Friday |
12/4 |
N-217/
GEN-S202 |
Tumor Immunity/ Immunotherapy |
Lanier |
Download PPT
Download Read List
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